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Characterization of the Rat MonoiodoacetateModel of Osteoarthritis: Evoked and Non-evoked Pain Response Assessments

by marc.wagner | Aug 24, 2023

Characterization and optimization of rat models of osteoarthritis pain to profile novel assets in support of the NIH HEAL Initiative Preclinical Screening Platform for Pain (PSPP)

by marc.wagner | Aug 24, 2023

Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain

by marcbacon | Feb 1, 2019

Kwan M Y, Choo A, Hanania T, Ghavami A, Beltran J, Shea J, Barboza A, Hu A, Fowler M, Rao N V, Sucholeiki I Int J Mol Sci. 2019 Feb; 20(4): 811. Published online 2019 Feb 14. doi: 10.3390/ijms20040811. There is an unmet medical need for the development of...

Effect of a novel, orally active matrix metalloproteinease-2 and-9 inhibitor in spinal and trigeminal rat models of neuropathic pain

by marcbacon | Sep 1, 2014

To study the effect of a novel matrix metalloproteinease-2 (MMP-2) and MMP–9 inhibitor, AQU-118, on mechanical allodynia in the spinal nerve ligation (SNL) model of neuropathic pain, and the chronic constriction injury of the infraorbital nerve (CCI-IoN) model of...
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