The triple reuptake inhibitor DOV216,303 exhibits limited antidepressant-like properties in the differential reinforcement of low-rate 72-second responding assay, likely due to dopamine reuptake inhibition.

Paterson, N. E.; Balci, F.; Campbell, U.; Olivier, B. E.; Hanania, T. J Psychopharmacol.2011 Doi: 10.1177/0269881110364272. Epub 2010 Mar 19. There is a need for antidepressants with novel mechanisms of action. One approach has been to develop compounds that inhibit...