by Desiree Cobb-Olori | Jun 24, 2025
Approximately 2% of individuals with ASD carry mutations in the Shank3 gene, which plays a crucial role in organizing neuronal connections. Shank3B-KO mice, developed by Professor Guoping Feng at MIT, harbor a deletion of exons 13-16 of the PDZ domains...
by Desiree Cobb-Olori | Jan 28, 2025
Fragile X Syndrome (FXS) is a genetic disorder caused by a CGG expansion in the Fmr1 gene. This condition tends to affect males more severely, while females often present a mosaic pattern of effects. Symptoms of FXS include: delayed crawling and walking, speech...
by marcbacon | Aug 16, 2020
Kabitzke, P, Morales, D, He, D, Cox, K, Sutphen, J, Thiede, L, Sabath, E, Hanania, T, Biemans, B, Brunner, D. Genes, Brain and Behavior. 2020;e12676. DOI: 10.1111/gbb.12676 Phenotyping mouse model systems of human disease has proven to be a difficult task, with...
by marcbacon | Sep 26, 2015
doi: 10.1371/journal.pone.0134572. eCollection 2015. Brunner D., Kabitzke P., He D., Cox K., Thiede L., Hanania T., He D., Sabath E., Alexandrov V., Saxe M., Peles E., Mills A., Spooren W., Ghosh A., Feliciano P., Benedetti M., Clayton AL., Biemans B. PLoS One 2015...
